5-Amino-1MQ (5-Amino-1-methylquinolinium) is a synthetic small-molecule compound studied in metabolic and obesity research. It is commonly investigated for its ability to inhibit the enzyme NNMT (Nicotinamide N-methyltransferase), which is involved in fat metabolism and cellular energy regulation.

Unlike many research peptides, 5-Amino-1MQ is not a peptide; it is a small quinolinium-based molecule used mainly in laboratory studies of metabolism and energy pathways.

What 5-Amino-1MQ Is

5-Amino-1MQ is a selective NNMT inhibitor designed to affect metabolic processes associated with fat storage and NAD⁺ metabolism. By blocking NNMT, researchers believe the compound may help regulate cellular energy balance.

Basic chemical information

• Chemical name: 5-amino-1-methylquinolinium

• CAS number: 42464-96-0

• Molecular weight: ~159.21 g/mol (cation form)

• Appearance: reddish-brown crystalline powder

How 5-Amino-1MQ Works

The compound targets the NNMT enzyme, which is often elevated in fat tissue.

Mechanism of action

1. Blocks NNMT enzyme activity

2. Helps preserve NAD⁺ (cellular energy molecule)

3. Reduces pathways linked to fat creation (lipogenesis)

4. May increase energy expenditure and metabolic activity

When NNMT is inhibited, cells may use nutrients more efficiently and store less fat.

Potential Research Areas

Scientists study 5-Amino-1MQ for several metabolic and longevity-related topics:

1️⃣ Fat metabolism research

Studies in animals suggest the compound may reduce white adipose tissue mass and influence body-weight regulation.

2️⃣ NAD⁺ and cellular energy

By affecting NAD⁺ metabolism, researchers explore its possible role in energy production and mitochondrial activity.

3️⃣ Longevity and metabolic health

It is also studied in experimental models related to:

• metabolic syndrome

• insulin sensitivity

• energy balance

Forms Available in Research

5-Amino-1MQ is typically supplied as:

• lyophilized powder in vials

• capsules (research or supplement markets)

Most laboratory products have ≥98–99% purity verified by HPLC testing.

Safety and Regulatory Status

Important points:

• 5-Amino-1MQ is not approved by the FDA for human use

• Most suppliers label it “for research use only”

• Human clinical trials are currently limited or unavailable

Summary

5-Amino-1MQ is a metabolic research compound that inhibits the NNMT enzyme and influences pathways related to NAD⁺ metabolism and fat storage. It is primarily studied in laboratory and animal models for potential applications in obesity, metabolic health, and cellular energy regulation, but it remains experimental and not approved for medical treatment.